These are the ones I have experience with and feel are worth mentioning.
Heroes Unlimited by Palladium Books (Heroes Unlimited™ RPG) is classic and still fun to play. Character creation is more stringent than most supers games, rooted in class-based progression but the system is solid.
I was introduced to Masks: A New Generation by Magpie Games (https://magpiegames.com/masks/) by folks here in the G&BS community. This is a coming of age, character-driven game built on the Powered by the Apocalypse engine. As a PbtA game, this is a very story-heavy game and it handles different kinds of supers very well. Your “Superman” can function alongside your “Batman” without having to worry about power level issues.
Trinity Continuum: Aberrant by Onyx Path Publishing (Trinity Continuum: Aberrant – Onyx Path Publishing( is the newest iteration of the Aberrant RPG. Built on Onyx Path’s new Storypath system which is similar to their classic d10-based Storyteller/Storytelling system but with more widgets for character-driven stories. This game comes with a heavy dose of setting as the game is set in the Trinity Continuum universe. Although one could easily ignore the setting and use the system for a different setting.
Mutants & Masterminds by Green Ronin Publishing (Mutants & Masterminds HQ - Green Ronin Online Store) is a solid system that handles various levels of play very well. This one is tried and true and is a community favorite. M&M 3E is probably the best edition of the game and has been going strong since 2011.
City of Mist by Son of Oak Game Studio (https://cityofmist.co/) is one I only recently discovered. Although not specifically “supers,” it is a game of “film-noir investigation and super-powered action.” Characters are “rifts,” ordinary people who become living embodiments of a legend, their “mythos.” This one is also Powered by the Apocalypse with tweaks to shape the system to the setting/game. I am still reading through the core books (PDF) but I am liking what I am seeing so far, so much so I ordered print copies.
I really like Marvel Heroic Roleplaying by Margaret Weis Productions (Marvel Heroic Roleplaying - Wikipedia). Unfortunately, this one is out of print as of 2013 as MWP did not achieve the level of sales needed to maintain the cost of the license. That was a real shame, IMHO, as I think MWP built a great game and produced really high-quality products. You can find copies of it on Ebay or HPB for as low as $40 for the core books.
I never owned or played DC Heroes but I did have a copy of the Batman Role-Playing Game by Mayfair Games (Batman Role-Playing Game - Wikipedia). Many fond memories of that one.
Teenage Mutant Ninja Turtles & Other Stranges by Palladium Books (Teenage Mutant Ninja Turtles & Other Strangeness - Wikipedia) gets an honorable mention. As a street-level game, it is a lot of fun. 100% compatible with Heroes Unlimited (see above).